Cognitive impairment in nondemented Parkinson's disease
Identifieur interne : 000361 ( Main/Exploration ); précédent : 000360; suivant : 000362Cognitive impairment in nondemented Parkinson's disease
Auteurs : Paolo Barone [Italie] ; Dag Aarsland [Norvège] ; David Burn [Royaume-Uni] ; Murat Emre [Turquie] ; Jaime Kulisevsky [Espagne] ; Daniel Weintraub [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-12.
English descriptors
Abstract
A substantial percentage of patients with newly diagnosed Parkinson's disease without dementia are reported to be affected by cognitive impairment (CI). In practice, however, CI is underrecognized, as the signs may not be apparent in early‐stage disease and many routine assessment tools lack the sensitivity to detect subtle cognitive dysfunction. Patients with PD and mild CI (MCI) may have a higher risk of developing dementia than cognitively intact PD patients; however, it is not currently known which patients with CI are at increased risk of developing dementia. This review summarizes current knowledge about CI in nondemented PD; it discusses the structural and functional changes associated with CI and addresses areas of unmet needs. We focus on questions that should be addressed in future studies to achieve consensus on its characteristics and definition, pathophysiology, epidemiology, diagnosis and assessment, and treatment and management. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23919
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-12">2011-12</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2483">2483</biblScope><biblScope unit="page" to="2495">2495</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">9A89F0CE3754B0A23F5E7DF5E4712ABC04D69B7E</idno><idno type="DOI">10.1002/mds.23919</idno><idno type="ArticleID">MDS23919</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CIND‐PD</term><term>Parkinson's disease</term><term>assessment</term><term>mild cognitive impairment</term><term>symptoms</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A substantial percentage of patients with newly diagnosed Parkinson's disease without dementia are reported to be affected by cognitive impairment (CI). In practice, however, CI is underrecognized, as the signs may not be apparent in early‐stage disease and many routine assessment tools lack the sensitivity to detect subtle cognitive dysfunction. Patients with PD and mild CI (MCI) may have a higher risk of developing dementia than cognitively intact PD patients; however, it is not currently known which patients with CI are at increased risk of developing dementia. This review summarizes current knowledge about CI in nondemented PD; it discusses the structural and functional changes associated with CI and addresses areas of unmet needs. We focus on questions that should be addressed in future studies to achieve consensus on its characteristics and definition, pathophysiology, epidemiology, diagnosis and assessment, and treatment and management. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Espagne</li><li>Italie</li><li>Norvège</li><li>Royaume-Uni</li><li>Turquie</li><li>États-Unis</li></country><region><li>Catalogne</li><li>Pennsylvanie</li></region><settlement><li>Barcelone</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name></noRegion></country><country name="Norvège"><noRegion><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Burn, David" sort="Burn, David" uniqKey="Burn D" first="David" last="Burn">David Burn</name></noRegion></country><country name="Turquie"><noRegion><name sortKey="Emre, Murat" sort="Emre, Murat" uniqKey="Emre M" first="Murat" last="Emre">Murat Emre</name></noRegion></country><country name="Espagne"><region name="Catalogne"><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name></region></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Weintraub, Daniel" sort="Weintraub, Daniel" uniqKey="Weintraub D" first="Daniel" last="Weintraub">Daniel Weintraub</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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